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The tech-heavy Nasdaq led a broad Wall Street decline on Tuesday with stocks falling more sharply after a healthcare bill was delayed in the US Senate, raising fresh questions about President Trump's domestic agenda.

The benchmark S&P 500 posted its biggest one-day drop in about six weeks and closed at its lowest point since May 31.

Major indexes extended losses after US Senate Republican Leader Mitch McConnell decided to put off a planned vote on a bill to dismantle the Affordable Care Act until after the Senate's July 4 recess.

The healthcare legislation, which has encountered resistance from several Republicans, is the first plank of Trump's domestic policy agenda, with investors eager for him to move onto his other plans including tax cuts, infrastructure spending, and deregulation.

Promises for such domestic polices helped fuel a 13.1-percent rise for the benchmark S&P 500 since Trump's Nov. 8 election.

"The market likes certainty, and now there's uncertainty," said Peter Costa, president of trading firm Empire Executions in New York. "What is this going to look like when this gets out of the next iteration? That uncertainty I think is just having people pause a little bit."

"I also think that when the market gets to certain levels, any type of uncertainty, especially in anything that has to do with the administration, will have an adverse effect," Costa said.

The Dow Jones Industrial Average fell 98.89 points, or 0.46 percent, to 21,310.66, the S&P 500 lost 19.69 points, or 0.81 percent, to 2,419.38 and the Nasdaq Composite dropped 100.53 points, or 1.61 percent, to 6,146.62.

Big tech names weighed most heavily on the S&P 500. Google parent Alphabet fell 2.5 percent after EU antitrust regulators hit the tech giant with a record USD 2.7-billion fine.

The Nasdaq had its worst day since a tech-led slide on June 9 raised questions about the sector.